“Friends” you would never be friends with in real life because they are assholes, debbie downers, sexists, racists, bigots, or homophobes.
Constant posters of TMI, boring, whiny, or otherwise unnecessary status updates.
People who stalk you online and/or post creepy comments on your wall or photos.
People with low self-esteem who constantly post flattering (at least in their opinion) pictures of themselves, in the hopes that someone they only barely know in real life will post a comment like “nice ass!” or “U R so pretty, can I be your real friend?”
People who constantly spam your message inbox and/or wall with junk completely irrelevant to you
Farmville (or similar game) players
Anyone who pokes you, unless the two of you engage in mutual poking